Sinemet 25/100 Initially 1 tab tid. Increase by 1 tab everyday or every other day. Max: 8 tab. Sinemet 25/250 Initially ½ tab once daily to bid. Add ½ tab everyday or every other day. Max: 8 tab.
Not recommended for drug-induced extrapyramidal reactions. CV diseases including history of MI or arrhythmias or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, history of psychoses or convulsions or wide-angle glaucoma. History of active peptic ulcer. Absorption of levodopa may be impaired in some patients on a high-protein diet. Discontinue use at least 6-8 hr prior to anaesth. Childn <18 yr. Pregnancy, lactation.
Dyskinesia including choreiform, dystonic & other involuntary movements. Mental changes including paranoid ideation & psychotic episodes; depression w/ or w/o development of suicidal tendencies; dementia; & GI disturbances.
N04BA02 - levodopa and decarboxylase inhibitor ; Belongs to the class of dopa and dopa derivative dopaminergic agents. Used in the management of Parkinson's disease.